Biochemical and histopathological studies of sulfonylurea derivative as a new chemotherapeutic agent against liver cancer in free- and nano-coated forms

Abstract The most frequent type of primary liver cancer is hepatocellular carcinoma (HCC), accounting for approximately 90% cancers and a third leading cause deaths. In the current study, synthesized compound 3 was re-formulated using tetraethyl orthosilicate (TEOS) with weight ratio (1:1) via sol-gel technique. prepared material has been examined Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray elemental analysis (EDX), scanning transmission electron microscopes (SEM TEM). Herein, we investigate mode action as potent anti-liver in vivo normal nano-forms. Rats were given single dosage 50 mg/kg b.wt. HCC through an intraperitoneal injection (ip). A CCl4 (2 ml/kg IP) also to rats 2 weeks later. Several liver, tumor oxidative stress biomarkers detected including enzymes; alanine aspartate aminotransferases (ALT AST), alkaline phosphatse (ALP), gamma glutamyl transferase (GGT), glutathione (GSH), lipid peroxide (MDA), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), ?-fetoprotein ?-L-Fucosidase. Hepatic pathological pictures performed documentation presence supported biochemical results. Moreover, DNA damage tissues male comet assay studied. results showed that HePG2 (? ve) group exhibited significant reduction (P < 0.05) values (9.30 ± 0.89) relative other treatment groups. Nevertheless, (+ 5-flurouracil groups significantly higher 0.01) compared group. Additionally, (coated ) ( decrease those